Inositol insulin insight
نویسندگان
چکیده
منابع مشابه
D-chiro-inositol glycans in insulin signaling and insulin resistance.
Classical actions of insulin involve increased glucose uptake from the bloodstream and its metabolism in peripheral tissues, the most important and relevant effects for human health. However, nonoxidative and oxidative glucose disposal by activation of glycogen synthase (GS) and mitochondrial pyruvate dehydrogenase (PDH) remain incompletely explained by current models for insulin action. Since ...
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The role of insulin in modulating phosphoinositide breakdown and accumulation of inositol phosphates was investigated in isolated rat pancreatic islets by using GPAIS (guinea-pig anti-insulin antiserum> that neutralizes effects of insulin in the medium. At either 3.0 mmor 16.7 mM-glucose or 3.0 mM-glucose plus I0 uM-arecaidine propargyl ester (muscarinic receptor agonist), GPAIS (but not contro...
متن کاملInositol, glycogen, insulin, and six nobelists.
Myreflections cover my scientific work over a sixty-year period. At the University of Michigan, I was initially interested in embryology. In medical school in the army, I became entranced with biochemistry and DeWitt Stetten, who introduced me to Carl Cori. Carl along with Gerty Cori and Earl Sutherland became my scientific mentors. After medical school and a nine-month medical internship, I re...
متن کاملInsulin Signaling: Inositol Phosphates Get into the Akt
An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of insulin signaling.
متن کاملPTB domain of insulin receptor substrate-1 binds inositol compounds.
We examined whether a phosphotyrosine binding (PTB) domain from the human insulin receptor substrate-1 (hIRS-1) is capable of binding inositol phosphates/phosphoinositides. The binding specificity was compared with that of the pleckstrin homology (PH) domain derived from the same protein because the three dimensional structure was found to be very similar to that of the PH domain, despite the l...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2011
ISSN: 1945-3477
DOI: 10.1038/scibx.2011.1